Pathways
Intrinsic Prothrombin Activation Pathway
Description:
The process by which the body prevents blood loss is referred to as coagulation. Thrombin/TFIIa (Activated Factor-II) is a multifunctional serine proteinase, which serves as an essential component of the process of Blood Coagulation - the hemostatic process of greatest interest. When a blood vessel is injured, bleeding is stopped by clotting (Coagulation) factors that form a thrombus (clot) of Fibrin threads which trap platelet aggregates and other blood cells. Clotting is a mechanism used by the body to stop bleeding. Our...
References:
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Rethinking the coagulation cascade.
Curr Hematol Rep. 2005 Sep;4(5):391-6. -
Platelets and thrombin generation.
Arterioscler Thromb Vasc Biol. 2002 Sep 1;22(9):1381-9. Review. -
A cell-based model of thrombin generation.
Semin Thromb Hemost. 2006 Apr;32 Suppl 1:32-8. -
Platelets promote coagulation factor XII-mediated proteolytic cascade systems in plasma.
Biol Chem. 2006 Feb;387(2):173-8.
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